"Lead researcher Dr Jeremy Farrar described the latest findings as "very worrying" - but said they were not surprising.
He said all microbes, whether parasites, bacteria or viruses, eventually started to develop drug resistance.
He said: "If this virus was to develop drug resistance and the ability to go from one person to another, that would clearly be a major problem."
However, Dr Farrar said there was some evidence to suggest viruses that developed drug resistance were also less likely to gain the ability to jump from person to person.
But he said the Vietnam findings stressed the importance of making sure the drug was only used in appropriate cases.
"We don't have a back-up at the moment, so we can't combine it with another drug, as we would with HIV, to prevent drug resistance developing."
Hay que mantener un ojo en este virus...
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